Tadalafil works by blocking the PDE5 enzyme, which increases the concentration of cGMP, a molecule essential for the dilation of the blood vessels in the penis. This facilitates an erection when the user is sexually stimulated.

Everything you need to know about Tadalafil 10 mg!

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Medically reviewed by Notre équipe éditoriale

Written by Anne-Sophie Laignel

Last updated 1/22/2025 - 6 min read

Tadalafil 10 mg is a well-known treatment for erectile dysfunction in men. This medication belongs to a class of substances called type 5 phosphodiesterase inhibitors (PDE5). It works by improving blood flow to the penis, thus allowing to achieve and maintain a satisfactory erection for sexual intercourse. This article explores how Tadalafil works, the mechanisms involved, and the duration of its effect.

Mechanism of action

Tadalafil primarily works by inhibiting the enzyme phosphodiesterase type 5, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP). This molecule plays a crucial role in the relaxation of smooth muscles and the dilation of blood vessels in the penile corpus cavernosum. By inhibiting PDE5, Tadalafil increases cGMP levels, which promotes better blood circulation and facilitates erection in response to sexual stimulation.

Unlike other similar medications such as sildenafil (Viagra), Tadalafil stands out for its prolonged duration of action. This characteristic makes it a preferred choice for many patients seeking more flexibility in their sexual activities.

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Dosage and Administration

A 10 mg dose of Tadalafil is often prescribed as the initial dose for most patients. It can be adjusted to 20 mg depending on efficacy and individual tolerance, or reduced to 5 mg if necessary. The medication is generally taken at least 30 minutes before sexual activity and can be consumed with or without food.

It is important to note that Tadalafil does not cause spontaneous erection: sexual stimulation is required for the medication to be effective. Moreover, the effect of Tadalafil can be influenced by the consumption of alcohol or certain fatty foods, which could slow down its absorption.

Duration of effect

One of the most notable features of Tadalafil is its long duration of action, which can last up to 36 hours. This means that a single dose can allow for spontaneous sexual intercourse over an extended period, without having to plan ahead. This lengthy period, often dubbed "the weekend pill," gives patients significant freedom and reduces performance-related stress.

However, it is essential to follow medical advice and not to take more than one dose per day. Excessive use could lead to serious side effects or complications.

Potential side effects

Like any medication, Tadalafil can cause side effects, although they are generally mild and transient. Among the most common side effects are:

  • Headache
  • Hot flashes
  • Nasal congestion
  • Muscle or back pain
  • Digestive troubles

In rare cases, more serious side effects may occur, such as priapism (prolonged and painful erection), sudden loss of vision or hearing, or allergic reactions. If these symptoms appear, it is crucial to seek immediate medical attention.

Contraindications and precautions

Tadalafil is not suitable for everyone. Patients with certain conditions, such as serious heart problems, severe liver or kidney failure, or those taking nitrate-based medications, should not use this treatment. These combinations can lead to a dangerous drop in blood pressure.

It is also recommended to discuss with a doctor before starting Tadalafil, in order to assess potential risks and ensure a

Tadalafil 10 mg is an effective treatment for erectile dysfunction, offering an extended duration of effect that stands out from other available options. By inhibiting PDE5 and increasing cGMP levels, it allows for improved blood flow and facilitates an erection responsive to sexual stimulation. However, as with any medication, it requires careful use and medical monitoring to minimize risks. With proper use, Tadalafil can significantly improve the sexual quality of life for patients.

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