Medically reviewed by Notre équipe éditoriale
Written by Anne-Sophie Laignel
Last updated 1/22/2025 - 6 min read
Tadalafil 5 mg, an approved medication for treating erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), is widely recognized for its effectiveness and extended duration of action. Here is a detailed exploration of how it works and its duration of effect.
Tadalafil is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for the breakdown of cyclic guanosine monophosphate (cGMP), a key molecule in the relaxation of smooth muscles. When a man is sexually stimulated, an erection occurs due to an increase in cGMP, which promotes blood flow to the erectile tissues of the penis. By blocking PDE5, Tadalafil allows cGMP to accumulate, thus amplifying the body's natural response to sexual stimulation.
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Tadalafil 5 mg is generally taken once a day, at the same time each day, with or without food. This low dose is designed for daily use, allowing for increased spontaneity in sexual relations. Unlike higher doses intended for one-time use, the daily dose maintains constant levels of medication in the blood.
One of the main characteristics of Tadalafil is its long duration of action, often referred to as 'the weekend pill'. Although the daily dose is lower than the high doses (10 mg or 20 mg), it allows for a continuous presence of the drug in the body. The elimination half-life of Tadalafil is about 17.5 hours, which means its effects can last up to 36 hours.
Several factors can influence the duration and effectiveness of Tadalafil:
Like any medication, Tadalafil 5 mg can cause side effects, although they are generally mild and temporary. Among the most common effects are headaches, muscle pain, hot flashes, and digestive disorders. Patients with cardiovascular diseases should consult their doctor before starting treatment, as Tadalafil can cause a drop in blood pressure.
Compared to other PDE5 inhibitors such as Sildenafil (Viagra) or Vardenafil (Levitra), Tadalafil stands out for its longer duration of effect. This provides increased flexibility for users, reducing the need to plan their sexual activities.
Tadalafil 5 mg is an effective treatment for erectile dysfunction and benign prostatic hyperplasia, offering an extended duration of effect and spontaneity in sexual relations. However, as with any medical treatment, it is essential to follow the doctor's recommendations and consider any potential contraindications.