Tadalafil 5 mg is an effective medication for managing erectile dysfunction and symptoms of benign prostatic hyperplasia.

Everything you need to know about Tadalafil 5 mg!

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Medically reviewed by Notre équipe éditoriale

Written by Anne-Sophie Laignel

Last updated 1/22/2025 - 6 min read

Tadalafil 5 mg, an approved medication for treating erectile dysfunction (ED) and benign prostatic hyperplasia (BPH), is widely recognized for its effectiveness and extended duration of action. Here is a detailed exploration of how it works and its duration of effect.

Mechanism of action of Tadalafil 5 mg

Tadalafil is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). This enzyme is responsible for the breakdown of cyclic guanosine monophosphate (cGMP), a key molecule in the relaxation of smooth muscles. When a man is sexually stimulated, an erection occurs due to an increase in cGMP, which promotes blood flow to the erectile tissues of the penis. By blocking PDE5, Tadalafil allows cGMP to accumulate, thus amplifying the body's natural response to sexual stimulation.

Main indications

  1. Erectile dysfunction: Tadalafil improves the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse.
  2. Benign prostatic hyperplasia: It reduces urinary symptoms such as difficulty urinating and frequent urges.
  3. Pulmonary arterial hypertension (in different dosages): It promotes the relaxation of blood vessels in the lungs.
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Dosage and Administration

Tadalafil 5 mg is generally taken once a day, at the same time each day, with or without food. This low dose is designed for daily use, allowing for increased spontaneity in sexual relations. Unlike higher doses intended for one-time use, the daily dose maintains constant levels of medication in the blood.

Duration of effect

One of the main characteristics of Tadalafil is its long duration of action, often referred to as 'the weekend pill'. Although the daily dose is lower than the high doses (10 mg or 20 mg), it allows for a continuous presence of the drug in the body. The elimination half-life of Tadalafil is about 17.5 hours, which means its effects can last up to 36 hours.

Factors influencing duration and effectiveness

Several factors can influence the duration and effectiveness of Tadalafil:

  • Age: Older patients may metabolize the drug more slowly.
  • Nutrition: Although Tadalafil can be taken with food, a high-fat diet may slow down its absorption.
  • Alcohol consumption: Excessive drinking can reduce effectiveness and increase side effects.
  • Underlying pathologies: Liver or kidney diseases can alter the drug clearance.

Side effects and precautions

Like any medication, Tadalafil 5 mg can cause side effects, although they are generally mild and temporary. Among the most common effects are headaches, muscle pain, hot flashes, and digestive disorders. Patients with cardiovascular diseases should consult their doctor before starting treatment, as Tadalafil can cause a drop in blood pressure.

Comparison with other treatments

Compared to other PDE5 inhibitors such as Sildenafil (Viagra) or Vardenafil (Levitra), Tadalafil stands out for its longer duration of effect. This provides increased flexibility for users, reducing the need to plan their sexual activities.

Tadalafil 5 mg is an effective treatment for erectile dysfunction and benign prostatic hyperplasia, offering an extended duration of effect and spontaneity in sexual relations. However, as with any medical treatment, it is essential to follow the doctor's recommendations and consider any potential contraindications.

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