Erectile dysfunction (ED) is a common complication associated with many medical treatments. Various medications, often used to treat chronic conditions, can have side effects that interfere with the ability to achieve or maintain an erection. Some drugs act directly on blood flow, nerves, or hormone levels, creating difficulties for sexual function. Among the main medications involved are beta-blockers like Inderal (Propranolol) and Tenormin (Atenolol), prescribed for hypertension, which reduce blood flow to the penis. Similarly, antidepressants such as Zoloft (Sertraline) and Prozac (Fluoxetine) affect neurotransmitters responsible for sexual arousal. Diuretics, such as Lasix (Furosemide), reduce the volume of circulating blood, thus creating a mechanical barrier to erection. Other hormonal drugs, such as Proscar (Finasteride) and Lupron (Leuprolide), often used for prostate disorders, lower testosterone levels, causing erectile dysfunction. Medications for hypercholesterolemia like Lipitor (Atorvastatin) and Crestor (Rosuvastatin) can also influence sexual function by altering hormonal balance. It is essential that patients and doctors are aware of these potential side effects in order to proactively manage them. This article presents the 50 most well-known treatments that can cause erectile dysfunction, citing the trade names of these medications. Solutions, such as adjusting the dosage or using alternative medications, can often help minimize the impact on sexual function. It is also possible to introduce specific treatments for erectile dysfunction, such as Viagra (Sildenafil) or Cialis (Tadalafil), to counter these effects while maintaining the main treatments.

Top 50 medications causing erectile dysfunction.

Dr. Sam Ward - Urologue et Andrologue

Medically reviewed by Dr. Sam Ward

Written by Anne-Sophie Laignel

Last updated 9/30/2024 - 7 min read

If you have erectile problems, erectile dysfunction and are taking treatments, read this article carefully.

Erectile dysfunction, or the difficulty in achieving or maintaining an erection, is a source of frustration for many men. This issue can be caused by various factors, including age, chronic diseases, or psychological factors. However, an often underestimated factor is the side effect of certain common medications. The best solution after reading this article carefully is to consult erection specialists, the doctors on Kano.care

Many medical treatments used to address serious conditions can have a negative impact on erectile function. Unfortunately, patients are poorly informed and often quite alone when dealing with this erection issue, which is not considered a major problem. Here is an overview of the top 50 medications known to cause erectile dysfunction.

1. Beta blockers (Propranolol, Metoprolol, Atenolol)

These medications, commonly prescribed to control blood pressure and heart diseases, reduce blood flow to the penis, making it difficult to achieve an erection.

2. Diuretics (Furosemide, Hydrochlorothiazide)

Diuretics, often referred to as "water pills," are prescribed for hypertension. They reduce the amount of blood circulating in the blood vessels, which can lead to erectile dysfunction.

3. Angiotensin-converting enzyme (ACE) inhibitors (Captopril, Enalapril)

Although effective in lowering blood pressure, these medications can cause a decrease in sexual desire and erectile dysfunction in some patients.

4. Antidepressants (SSRIs, tricyclics)

Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, are commonly used to treat depression and anxiety. These medications affect the brain's neurotransmitters, sometimes reducing libido and making it difficult to achieve an erection.

5. Antipsychotics (Haloperidol, Risperidone)

These medications, used to treat schizophrenia or bipolar disorders, affect the neural pathways responsible for erection.

6. Antihistamines (Diphenhydramine, Cetirizine)

Used to treat allergies, some antihistamines can cause erectile dysfunction by blocking the production of enzymes necessary for an erection.

7. Cholesterol medications (Statins, Fibrates)

Statins, although beneficial for reducing cholesterol levels, can affect testosterone production, leading to erectile dysfunction.

8. 5-alpha-reductase inhibitors (Finasteride, Dutasteride)

These medications, used to treat benign prostatic hyperplasia and baldness, reduce testosterone production and are associated with erectile dysfunction.

9. Prostate cancer medications (Leuprolide, Goserelin)

These treatments directly affect hormone levels and can cause a loss of erectile function by reducing testosterone levels.

10. Antihypertensives (Nifedipine, Amlodipine)

These medications dilate blood vessels to lower blood pressure, but they also reduce blood flow to the penis, causing erectile dysfunction.

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11-50. Other medications commonly associated with erectile dysfunction

The following list includes other medications that can cause erectile dysfunction, although to a lesser extent:

  1. Clozapine (antipsychotic)
  2. Paroxetine (SSRI antidepressant)
  3. Venlafaxine (SNRI antidepressant)
  4. Spironolactone (diuretic)
  5. Methotrexate (treatment for cancer and rheumatoid arthritis)
  6. Morphine (opioid analgesic)
  7. Codeine (pain reliever)
  8. Diazepam (anxiolytic)
  9. Lorazepam (anxiolytic)
  10. Clonazepam (anxiolytic)
  11. Carbamazepine (anticonvulsant)
  12. Phenytoin (anticonvulsant)
  13. Tamoxifen (anticancer)
  14. Amitriptyline (tricyclic antidepressant)
  15. Cyclobenzaprine (muscle relaxant)
  16. Isosorbide (vasodilator)
  17. Digoxin (treatment for heart failure)
  18. Trazodone (antidepressant)
  19. Fluoxetine (SSRI)
  20. Chlorpromazine (antipsychotic)
  21. Promethazine (antihistamine)
  22. Lisinopril (IEC)
  23. Quinapril (IEC)
  24. Atorvastatin (statin)
  25. Simvastatin (statin)
  26. Valproic acid (anticonvulsant)
  27. Gabapentin (anticonvulsant)
  28. Buspirone (anxiolytic)
  29. Tramadol (pain reliever)
  30. Oxycodone (pain reliever)
  31. Meprobamate (anxiolytic)
  32. Thioridazine (antipsychotic)
  33. Hydralazine (antihypertensive)
  34. Prochlorperazine (antipsychotic)
  35. Cetirizine (antihistamine)
  36. Metformine (antidiabétique)
  37. Glyburide (antidiabétique)
  38. Allopurinol (traitement de la goutte)
  39. Tolterodine (traitement de l’incontinence)
  40. Baclofène (antispasmodique)

Managing Medication-Related Erectile Dysfunction

It is essential for patients experiencing erectile dysfunction related to medications to consult their doctor. Often, there are alternative medications that do not cause these side effects. Solutions such as Viagra or Cialis may also be considered.

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Dr. Sam Ward - Urologue et Andrologue

Révision médicale par le Dr. Sam Ward

Directeur médical, Urologue et Andrologue

Le Docteur Sam Ward, urologue et andrologue, dirige le service d'urologie à la Clinique Saint-Jean de Bruxelles depuis octobre 2024. Membre du Comité exécutif de la Chaire UNESCO Santé sexuelle & Droits humains et cofondateur de Kano.care, il est spécialise en santé masculine et médecine sexuelle.

En savoir plus sur notre équipe médicale

Reviewed on 6/6/2025

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Treatments for erectile dysfunction, such as Viagra®, Cialis®, Levitra®, and Spedra®, carry potential risks that vary depending on the patient's health condition. They may cause serious side effects, including cardiovascular issues, dangerous drug interactions, or prolonged erections (priapism), which require immediate medical attention. It is essential never to take these medications without the advice of a qualified healthcare professional. A thorough medical consultation is necessary to determine the appropriate treatment for each individual, taking into account medical history and contraindications. Additionally, it is crucial to ensure that the medications are obtained from reliable and authorized sources. Medications purchased outside legal channels or without a prescription may be counterfeit, ineffective, or even harmful to health. Always consult a doctor before using these treatments and obtain medications from a licensed pharmacy.

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